Regulation of vascular tone and blood pressure through endothelial mechanosignaling

Endothelial regulation of vascular tone.

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall

The identity of the specific nitric oxide dioxygenase (NOD) that serves as the main in vivo regulator of O2-dependent NO degradation in smooth muscle remains elusive. Cytoglobin (Cygb) is a recently discovered globin expressed in fibroblasts and smooth muscle cells with unknown function. Cygb, coupled with a cellular reducing system, efficiently regulates the rate of NO consumption by metaboliz...

Vascular mineralocorticoid receptor and blood pressure regulation.

The mineralocorticoid receptor (MR) is a major regulator of blood pressure by modulating sodium balance and blood volume in the distal nephron. The discovery of MR expression in both endothelial and vascular smooth muscle cells a decade ago raised questions about its role in the vascular wall and its involvement in blood pressure regulation. In vitro and in vivo pharmacological studies have sho...

Vascular cytochrome P450 in the regulation of renal function and vascular tone: EDHF, superoxide anions and blood pressure.

Sodium gradient, smooth muscle tone, and blood pressure regulation.